At the end of this essay, we observe that 
and 
are
important parameters for influencing the global properties of
RNA. They are as significant as the persistence length (
). These
virial coefficients strongly influence the behavior of the rms
end-to-end separation-distance. The effect is global and therefore
not negligible. In understanding RNA folding, it is these seemingly
insignificant parameters that drastically change the course of RNA
folding.