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At the end of this essay, we observe that $B_2$ and $B_3$ are important parameters for influencing the global properties of RNA. They are as significant as the persistence length ($\xi$). These virial coefficients strongly influence the behavior of the rms end-to-end separation-distance. The effect is global and therefore not negligible. In understanding RNA folding, it is these seemingly insignificant parameters that drastically change the course of RNA folding.

Wayne Dawson 2007-01-10